Enteroviral infections are difficult to diagnose, and better diagnostic procedures are clearly needed. After the acute phase of an infection, enteroviruses can leave the blood and cerebrospinal fluid completely, spreading to organs and other tissue. This makes it difficult to diagnose enteroviral infections without a biopsy, and even then, the tests are limited.

The EV Foundation is working with scientists and diagnostic companies to develop better diagnostic tools for detecting these viruses more quickly, less invasively, and with methods that will work in less advantaged areas of the world.

Listed below are clinical laboratory tests for acute enteroviral infections, clinical laboratory tests for persistent enteroviral infections, imaging tests and other tests. After explanations of the tests, there is a section of bulleted notes from Dr. John Chia to assist with diagnosis.